Can mean a few things. 1) Doing something while running, like 'kumain nang **patakbo**' (eating while running), which is how you live life during finals week. 2) An event, like a fun run ('Sumali ako sa **patakbo**'). 3) The management or operations of something, like the **patakbo** of a BPO account. It's the Pinoy hustle in one word.